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It is highly expressed on plasmablasts, plasma cells, and memory B cells, with particularly elevated levels observed on LLPCs in the bone marrow (94) ( Figure 2 )

doi: 10.15258/sst.2010.38.1.04 28 ChenX.-J.YinY.-Q.ZhuX.-M.XiaX.HanJ.-J

ACTIVATION PRESERVES GUT BARRIER INTEGRITY BY SUPPRESSING INTESTINAL EPITHELIAL CELL NECROPTOSIS: PROTECTIVE ROLE IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS Akiko Sugiyama 1 Susan Hagen 2 David Cohen 1 , 1 Brigham and Women's Hospital, Harvard Medical School, 2 Beth Israel Deaconess Medical Center, Harvard Medical School Background: Acyl-CoA thioesterase 12 (Acot12), a cytosolic enzyme that hydrolyzes acetyl-CoA into acetate, is expressed in small intestinal epithelial cells (IEC) and is markedly induced by high fat diet (HFD) feeding

A.WeerapanaE.et al (2019)