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Research has characterised MT-1s ability to confer photoprotection through mechanisms operating independently of melanin synthesis , documenting enhanced nucleotide excision repair activity, reduced cyclobutane pyrimidine dimer accumulation following UV challenge, and antioxidant pathway upregulation in MT-1-treated melanocytes and keratinocytes

Statement #48: Grade of recommendation D The administration of antioxidants is potentially beneficial for MMA and PA patients, but needs to be confirmed in prospective clinical studies

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