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When the UPR fails to clear misfolded proteins through proteasomal degradation, cells are unable to resolve ER stress, leading to apoptosis and subsequent degradation of TM tissue

The Trx system is commonly recognized as comprising of thioredoxin (TXN, Trx), thioredoxin reductase (TXNRD, TrxR), and nicotinamide adenine dinucleotide phosphate (NADPH)

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560,561 In a randomized placebo-controlled trial in 20 subjects with type 2 diabetes, 400 mg green tea extract daily for 12 weeks reduced arterial stiffness

Spinach is very versatile and can be cooked, added to many dishes or eaten raw