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Keywords: AEDG tetrapeptide, Diabetic retinopathy, Epithelial-mesenchymal transition, Oxidative stress, Wound healing Introduction Retinal pigment epithelial (RPE) cells, which lie between the choroid and neurosensory retina, constitute the outer blood-retinal barrier and play a crucial role in the pathological processes that lead to vision loss

The peptide's unique molecular mechanisms involving angiogenesis pathway activation, growth hormone receptor upregulation, and anti-inflammatory modulation distinguish it from conventional therapeutic approaches and provide biological rationale for its observed effects in experimental models

Processes under astrocyte control including glutamatergic signaling (Beaul et al., 2009) are regulated through the molecular clock, and in addition, extracellular glutamate displays rhythmicity, peaking during the mid-late day (inactive period) in mice

While peptides are still considered an emerging treatment option, the results were seeing in our patients are nothing short of impressive

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