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BOMSS guidelines recommend starting B12 supplementation post-operatively and continuing lifelong, with blood monitoring beginning at three months after surgery

however, phenol and tyrosol were still accepted (after a reaction time of approximately 20 hours) as demonstrated by the substrate scope assay (Fig

This personalized strategy, based on the principles of personalized medicine, could allow for more effective targeting of senescent cells in specific situations, offering another promising direction for advancing senotherapy

Looking ahead, centralized multimodal repositories that integrate transcriptomic, proteomic and imaging data across neurological diseases will be essential to standardize reactive astrocyte definitions and foster cross-laboratory collaboration, ultimately refining subtype classification and accelerating translation