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TP53-mutated acute myeloid leukemia and myelodysplastic syndrome: biology, treatment challenges, and upcoming approaches

Hemoglobin and tissue oxygenation in aging Efficient tissue oxygenation is fundamental to maintaining cellular metabolism, organ function, and overall health throughout the lifespan

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The HIF-1 target BNIP3 interacts with Rheb, a key activator of mTOR, thereby mediating hypoxia-induced inhibition of mTOR activity

These effects reflect the vast and diverse biological mechanisms through which diet interacts with human physiology ( 3.1 Cardiometabolic health Plant-based diets can impact cardiometabolic health through various means such as effects on lipid profiles, systemic inflammation reduction, insulin sensitization, and effects on body weight ( Plant-based diets have been consistently associated with lower body mass index, which considered as one of the major drivers of cardiometabolic risk and additionally with lower incidence of obesity