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Pregnant and nursing women known to be heterozygous for the deficiency also should avoid ingestion of drugs with oxidant potential, because some gain access to the fetal circulation and to breast milk

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People with active cancer or history of cancer within 5 years should avoid use because growth factors and angiogenesis promotion could theoretically affect tumor growth

Furthermore, the GSH-dependent antioxidant enzymes (glutathione peroxidase-1, glutathione reductase, glutathione S-transferase) cooperate and are interconnected reactions that eliminate ROS or controlled the redox state