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1, following the confirmation of diabetes, oral treatments were administered once daily for additional four weeks in the respective groups according to the treatment as follows: The control group was subdivided into two subgroups (n = 16) to: NC group : Untreated normal control group received the vehicle (a single intraperitoneal injection (i.p.) of 0.1 M sodium citrate buffer, pH 4.5 at the end of week four and corn oil via oral gavage once a day for four weeks

The binding affinity of wild-type and mutant PV2 and PV3 to the antigen PD-L1 was also characterized by ELISA (Fig

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