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Targeting lactylation epitopes in combination with existing immunotherapies may hold clinical translation potential

Mostofa, M

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Wild-type (WT) and G3BP1/2 double knockout (dKO) GSCs were performed for immunoblotting analyses with the indicated antibodies (n = 3)

The canonical pathway is primarily triggered by MSU crystals through NLRP3 inflammasome activation and caspase-1 signaling, whereas the non-canonical pathway is mediated by caspase-4/5 in humans (caspase-11 in mice) in response to intracellular LPS