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TGF-1 expression is increased in ligated UOO mouse kidneys 56 or kidneys of patients with diabetic nephropathy 57 and circulating TGF-1 is elevated in conditions that are risk factors for CKD including hypertension, dyslipidemia and T2D 58

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The pantethine derivative cysteamine may also function to reduce the activity of liver enzymes that produce cholesterol and triglycerides

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Nanomedicines ability to precisely control ICD induction presents a promising approach for combining direct cancer cell killing with immunotherapy

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