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While direct evidence from silicosis models is still needed, this mechanistic insight suggests that targeting ferroptosis via stem cell paracrine signaling could represent a promising therapeutic approach against silica-induced pulmonary fibrosis

Betzel, Alessandra Griffa, Patric Hagmann, and Bratislav Mii

Modulating Dnmt3a or Tet2 expression has shown potential in reversing age-related memory impairments (166).Tau proteins, essential in AD DNA methylation, are instrumental in regulating genes linked to A and tau pathways (167)

People with compromised immune systems, chronic respiratory conditions, or genetic susceptibilities are particularly vulnerable

However, some overlap exists, as an increase in TREM2, APOE, MHC-II, HLA-DRA, and CD68 genes are shown in humans and 5xFAD mice