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supporting the feasibility of treat-smart personalized therapy rather than non-specific escalation

(3) Additional use: Pyridostigmine is also used as prophylaxis against organophosphate nerve agents (e.g., soman) in military settings

doi: 10.1186/s12915-022-01325-z 86 HiltonB

doi: 10.1002/acn3.580 107 HancockDBMartinERStajichJMJewettRStacyMAScottBLet al

149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages