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Cisplatin-resistant OSCC cells suppress ferroptosis through upregulation of the SLC7A11-GSH-GPX4 axis, while reactivating ferroptosis can restore cisplatin sensitivity and reverse the resistant phenotype ( inhibitor erastin promotes ferroptosis via a ROS-dependent mechanism, enhances cisplatin cytotoxicity in OSCC cells, and exhibits no overt toxicity in vivo , providing a clinically translatable approach to overcome cisplatin resistance

#Fisetin #LongevityIndustry #NutraceuticalIngredients #AntiAgingScience #Senolytics #ProductDevelopment #IngredientStrategy To view or add a comment, sign in Our research suggests that specific processing of distinct hibiscus sabdariffa (aka sorrel) may help cells slow biological aging and even protect against iron generated free radicals