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Maniatis, N

It was suggested that the negative effects of LCKD were associated not with ketone bodies themselves but rather with enhanced release of free fatty acids from the adipose tissue and the correspondent increase in peroxisome proliferators-activated receptor (PPAR) transcription factors with many undesirable effects like development of the atherosclerosis as one example (Kersten et al., Roles of cPHB in health and disease Elevated levels of plasma -OHB observed in HF and diabetes could potentially lead to increased accumulation of cPHB

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