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Biochim Biophys Acta Mol Cell Biol Lipids

doi: 10.1038/nrd795 97 WangJLobergRTaichmanRS

The hydrogen bonds and hydrophobic interactions that hold semaglutide in its active configuration begin weakening at temperatures well below boiling, and once enough bonds break, the molecule cannot refold into its functional shape

Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia

It may be worth trying high dose oral/sublinguals in between injections - they can be effective for some patients - even those with PA - but don't help everyone