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As melanin synthesis generates ROS, aging leads to a decline in antioxidants like catalase, glutathione, and SOD, creating an imbalance

Jan 1 2015;55(1):e15-25

References Bounous G and P Gold

In general, pain in PD is usually the result of inadequate dopaminergic therapy, improving if a more continuous stimulation of dopaminergic receptors with levodopa is achieved, adding COMT inhibitors or dopamine agonists

Another way that acetyl-L-carnitine may support normal nervous system function is by imparting neuroprotective and neurotrophic effects, which includes influencing the action of nerve growth factor and promoting peripheral nerve regeneration and repair