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PMID 34196817 Microneedling with RF for Rosacea: Observational Study Results Efficacy and Safety of Non-Insulated Fractional Microneedle Radiofrequency for Treating Difficult to treat Rosacea: A 48-Week Prospective Observational Study Arch Dermatol Res 2022 Sep;314(7):643-650 Results: Among 34 patients, 22 reported good or excellent improvement and 30 were very or relatively satisfied

Allowing the powder to reach room temperature before adding water prevents thermal shock that denatures the peptide structure

Reduced inflammatory cytokine activity, improved microvascular integrity, and beneficial effects on pain modulation through peripheral and dopaminergic mechanisms are among the reported effects in animal studies