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It is followed by the partitioning into the sebum followed by the diffusion through the lipids

Anal Bioanal Chem 414(14):41794188

J Gastroenterol Hepatol (2023) 38:133345

2022;45:e14167

Targeting of STAT3 and STAT5 by a novel drug- combination employing ponatinib and bardoxolone methyl (CDDO-Me) leads to synergistic effects in BCR/ABL-T315I-mutated cells in Ph+ CML