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[PMC free article: PMC3671347] [PubMed: 23761782] 51

The potentially beneficial features of IgE include its affinity for the FcR, expressed by the immune effectors responsible for ADCC and ADCP, and the low levels of normal IgE in the blood, which avoids competition with the therapeutic IgE

Enzymatic generation of the antimetabolite ,-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete

These substances interfere with thyroid function, causing epigenetic changes, and can cause disease by directly damaging thyroid cells or stimulating the immune system (Andrade et al