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It is suspected that these compounds can stimulate the synthesis of reactive oxygen species in two ways: by stimulating an endogenous source or by transforming the compound (85)

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It is possible that the supplements did not triggercancer but rather accelerated the progression of existing undiagnosed cancers, making later discovery of the disease likely.In other words, it could be that while antioxidants might prevent DNA damageand thus impede tumor initiationonce a tumor is established, antioxidants might facilitate the malignant behavior of cancer cells, Schafer says

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Cells cultured in low folate or treated with sub-IC50 concentration of methotrexate proliferated slower than the controls, and this fitness defect is completely blunted while culturing cells in galactose (Fig