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This study was retained in the DCD analysis due to its rigorous methodology, with its larger sample size (227 participants) and extended 12-month follow-up period likely contributing to the observed differences in effect size

For example, the excitatory signal from the entopeduncular nucleus to the lateral habenula is limited by GABAergic cotransmission, but during cocaine withdrawal, the presynaptic vesicular GABA transporter is reduced, resulting in a decrease in this inhibitory component and causing relapse

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Tissue Trauma and Long-Term Protocol Adherence Repeated IM injections into the same muscle group