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The tAPX was down-regulated after 15 days of stress in rice, several other isoforms were up-regulated, still some microsomal isoforms were slightly or not affected at all (Rosa et al., 2010)

10.1111/bpa.12655 Brain Pathol

Because the carrier frequency of each of the two common HFE pathogenic variants, p.Cys282Tyr and p.His63Asp, is very high among people of European ancestry, screening should be offered to the first-degree relatives of individuals who have HFE-related hemochromatosis