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Series 2: 3-AR knock-out mice (the gene for the 3 receptor is knocked out) in the same design, to check whether 3 is necessary for the AOD-9604 effect

In practice, injections are used when rapid correction or assured absorption is needed

To achieve a steady state or to ensure the compound is present and active for a significant portion of the day, researchers typically opt for multiple administrations per day

For example, if the target daily dose is 100mg for a research subject, a protocol might involve 50mg in the morning and 50mg in the evening

This helps prevent receptor desensitization, keeps results consistent, and minimizes unwanted side effects