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The cost of discarding a partially degraded large vial often exceeds the negligible price difference of buying smaller units, making multiple small vials the more cost-effective choice for extended protocols

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This effect was abrogated by inhibiting NOSs or guanylate cyclase, implicating NO/cGMP signaling pathway in this process (Aquilano et al., 2013)

Mechanisms of resistance to anti-CD38 daratumumab in multiple myeloma