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ER receptor is encoded by the ESR2 gene

The representative experiment (of five) is presented

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Moreover, the significant therapeutic potential of gene interventions targeting the p53- FOXO3 regulation of cartilage degeneration at the cartilage level and abnormal remodeling in the subchondral bone during obesity-induced degeneration were elucidated

When this happens, the gradual buildup of dysfunctional mitochondria can lead to increased inflammation, which is associated with a higher risk of chronic diseases, like cancer or dementia.8 15 So, if urolithin A can kickstart mitophagy, then it may lower your risk for chronic disease, increasing your healthspan and your lifespan