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The compounds low oral bioavailability and limited ability to cross the blood-brain barrier are challenges that still need to be addressed

10.1016/j.surg.2004.03.012 63 MatsumotoK.MiyakeY.UmedaY.MatsushitaH.MatsudaH.TakakiA.et al (2013)

These models highlight distinct pathological and temporal features of AD, including early synaptic changes and amyloid accumulation, providing valuable tools for studying disease progression and potential therapeutic targets