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As low dose of ferroptosis-inducing agents mimics the effects of gpx-3(tm2059) , gpx-5(tm2024) and gpx-8(tm2108) mutations, while high dose mimics the effects of gpx-1(tm2100) and gpx-4(tm2111) mutations, its possible that loss of GPX-3, GPX-5 or GPX-8 leads to a low level of lipid oxidation, and loss of GPX-1 or GPX-4 causes a higher level of lipid oxidation