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In this article, we demonstrated that V-ATPase dysfunction has a dual effect on autophagy: on the one hand, it impairs lysosomal/vacuolar hydrolytic activity to inhibit the final step of autophagy

b , NAD + levels in several tissues (liver and spleen n=5 mice except for Ctrl CD38 KO where n=4

The shorthand 5-Amino-1MQ describes a quinolinium scaffold bearing a methyl substituent at the ring nitrogen (1-methylquinolinium) and an amino group at the 5-position

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