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In addition to a decrease in peripheral levels of LAC, LAC levels are decreased by 4060% in the hippocampus and prefrontal cortex of rodents with depressive-like behaviors, including the Flinders Sensitive Line (FSL) rats [30]
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This positive signal is further corroborated by another recent umbrella review, which highlighted that Coenzyme Q10 consistently demonstrates beneficial effects on cardiac function and clinical outcomes across meta-analyses ( 3.3 Emerging data in heart failure with preserved ejection fraction and endothelial function A 2022 phase II, double-blind, randomized trial in patients with preserved ejection fraction (HFpEF) reported that ubiquinol (600 mg/day), alone or combined with D-ribose, modestly enhanced LVEF and alleviated symptom burden, though exercise capacity improvements were inconsistent ( 3.4 Statin-associated myopathy Although there is mechanistic plausibility for Coenzyme Q10 in alleviating SAMS, a 2021 meta-analysis identified no significant improvements in myalgia or creatine kinase levels relative to placebo (Wei et al., 2022)
