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The hydroxyl group on the side chain of shikonin provides an ideal modification site for optimization, and the most effective compound (R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 2-((5-(4-bromobenzyl)-1,3,4-thiadiazol-2-yl)thio)acetate (PMMB-187) was obtained by using scaffold growth strategy

The Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, the Editorial Board, Chinese Journal of Pediatrics, China Medicine Education Association Committee on Pediatrics