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Our meta-analysis has provided encouraging evidence, demonstrating the positive impact of AOX therapy on clinical pregnancy rate, seminal parameters, and OS levels in men for whom a careful diagnostic evaluation has excluded major comorbidities, genetic, anatomical, inflammatory, traumatic or testicular cause of male infertility, or associated female infertility (Supplement Table 3)

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The zinc coordination is more static, and zinc is consistently bound to three hisidine and one aspartate side chain (see Figure below)

Physical property changes Reconstitution difficulties may indicate degradation