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Feb 28 2018;19(3)doi:10.3390/ijms19030686 Martnez-Gonzlez MA, Sayn-Orea C, Bulln-Vela V, et al

10.2147/JIR.S306849 [DOI] [PMC free article] [PubMed] [Google Scholar] Zafar S., Yaddanapudi S

Modern prescribing today: transdermal estradiol plus micronized progesterone, and why the formulations matter

see figure 13 in [10]

It is recommended to start with a low dose of the peptide combination and gradually increase it over time in order to minimize the risk of side effects