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Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

The concomitant modulation of Nrf2 suggests that a functional AGE/RAGE-Nrf2 axis contributes to this protective effect

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There was also an improvement in the ratio of GSSG to GSH, with the largest decrease in this ratio among those taking the higher dose in the first and second weeks

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