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3 Definition, pathophysiology, risk factors of DPN 3.1 Definition DPN is considered a symmetrical, length-dependent sensorimotor polyneuropathy attributable to metabolic and microvascular alterations due to chronic hyperglycemia exposure (diabetes) and cardiovascular risk covariates ( DPN progresses gradually with increasing duration of diabetes and in relation to glycemic control in both T1D and T2D ( 3.2 Pathophysiology Although the exact pathophysiology of DPN remains unknown, the role of various signaling cascades has been proposed such as advanced glycation end-product (AGE) pathway, polyol pathway, protein kinase C (PKC) pathway, hexosamine pathway and poly (ADP ribose) polymerase (PARP) pathway (29)

Understanding these genetic factors may help provide context for whether liposomal glutathione aligns with your metabolic profile, though genetic variants do not determine exact supplement response

10 mL bottles are standard

Oct 2014;18(5):415-24

Novel therapies for MCL