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Due to different intracellular and extracellular functions HMGB1 is a central mediator in inflammation and immunity, but its activity depends on the state of its redox-sensitive cysteine residues at positions 23, 45 and 106 ranging from DNA binding, to induction of chemotaxis and transcription of chemokines [197, 198] suggesting its classification as an alarmin for sepsis and cancer [199]

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