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AD as a metabolic iceberg AD may be conceptualized as a metabolic iceberg, with the hallmark clinical, anatomical, and pathological features emerging as late-stage effects of impaired mitochondrial biology (Fig

77 A Cochrane review of the use of NAC in children with respiratory infections evaluated the safety data from 34 clinical trials, involving 2064 children, and found NAC to be safe, although the authors note that 59 cases of paradoxically increased bronchorrhoea (increased sputum production) in infants under the age of 2 years were reported to the French pharmacovigilance system

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Moreover, it curbs ROS production and amplifies NO availability in endothelial cells, thus averting acute alcohol-induced endothelial dysfunction (201)