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96 The iron from lysosomes appears to be taken up into mitochondria, contributing alongside ROS to the opening of the MPTP and subsequent cell death

Biochem J 410:525534 Hong SH, Lee D-H, Lee Y-S et al (2017) Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression

This is particularly important for essential and abundant proteins whose overoxidation would lead to loss of cell viability and requires new protein synthesis to replace inactivated proteins