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PARP or ATM/ATR inhibitors may increase genomic instability in normal tissues due to off-target effects, with long-term PARP inhibitor use potentially inducing hematopoietic malignancies and ATR inhibitors exhibiting hepatotoxicity in mouse models (196,204,211,212)

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Then, raw sequence reads were trimmed to remove possible adapter sequences and nucleotides with poor quality using Trimmomatic v.0.36

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