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Aunque su funcin fisiolgica exacta an se est estudiando, el DSIP se ha asociado con la modulacin de la actividad hipotalmica e hipofisaria en modelos experimentales

How the Met allele affects BDNF secretion The Met allele disrupts the interaction between proBDNF and sortilin, a protein that directs BDNF into regulated secretory vesicles

When this system becomes disrupted, patients may experience symptoms such as abdominal pain, bloating, diarrhea, constipation, urgency, food sensitivity patterns, fatigue, or systemic inflammatory complaints

doi: 10.1016/j.scr.2019.101605 58 MaZLiLLivingstonMJZhangDMiQZhangMet al

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