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As mentioned, some clinics have already started applying this NNMT inhibitor to humans, even though the FDA has made no ruling on its safety, making human trials paramount

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For instance, an IgG-Fc conjugated ancestral Wuhan-Hu-1 RBD sequence adjuvanted with a novel STING agonist CF501 induced potent nAb activity against SARS-CoV-2 Omicron and XBB variants in macaques, mice, and rabbits [159, 160] (Table 2)

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