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Multiple high-throughput screening campaigns against class B GPCRs had yielded very few small-molecule hits, and those that did emerge typically showed weak activity or failed to progress beyond early preclinical stages

B.) 6774.2010 (Gerace Research Centre, San Salvador, 2010)

This potentiation may be dependent on the stimulation of serotonin receptors, as blocking these receptors with GR 125487 appeared to eliminate the synergistic actions observed with RS 67333

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