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These findings provide valuable evidence to counsel patients with hepatic adenoma undergoing IVF that monitoring the adenomas without intervention is likely safe and appropriate

However, overexpression of Pfkfb3 activates glycolysis in neurons through the APC/C-Cdh1 pathway, which inhibits the pentose phosphate pathway (PPP), reduces the oxidation of glucose-6-phosphate (G6P), decreases the production of reduced glutathione, and finally leads to oxidative stress and apoptosis (Herrero-Mendez et al., 2009)

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