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These variants subsequently cause a RAS-protein gain of function associated with enhanced GTP activity, since GTPase-activating proteins (GAPs) are unable to bind KRAS, thus increasing the intrinsic GTPase activity of KRAS (Johnson et al

Secondly, the balance of GSH and GSSG is shifted toward GSSG via the GPX and GR reactions

Senol, A., Yucelten, A

10.1111/cns.13548 CNS Neurosci

In Alzheimers disease models of Drosophila expressing wild-type human amyloid-beta 42, kaempferol alleviates symptoms by reducing oxidative stress in the brain (Han et al., 2019)