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Immunofluorescence analysis corroborated these findings, showing significant reduction of DLAT aggregates with DEX intervention (Figure 8)

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Blood-to-bile water movement at the ductular level is facilitated by constitutive AQP4 in the basolateral membrane, and secretin-stimulated AQP1 in the apical membrane.46 On the other hand, absorption of ductular water and electrolytes is driven by the osmotic gradients created by bile-to-plasma transport of electrolytes and organic solutes