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Furthermore, when ROS exceeds a certain threshold, it leads to oxidative stress ( Mechanisms governing ferroptosis Ferroptosis, unlike apoptosis, autophagy, and cell necrosis, is a regulatory form of cell death that depends on iron and ROS

Acknowledgments We gratefully acknowledge the assistance of Home for Researchers for language modification

Chronic dysregulation of these UPR pathways leads to enhanced cardiomyocyte apoptosis, inflammation, and structural deterioration, forming a key mechanism underlying ER dysfunction in diabetic cardiomyopathy ( 6.2.2 Ca 2+ leakage The ER functions as the main intracellular calcium reservoir

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