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Nuclear receptor coactivator 4 (NCOA 4) serves as a selective cargo receptor that targets ferritin to autophagosomes (Le et al., 2024)

Liu, P., Zhang, Y

doi: 10.1038/s41392-023-01588-0 52 GellaA.DuranyN

After 72 h, the resulting solution was freeze-dried by using low-temperature freeze dryers, yielding P1(1.23 g) as a yellow powder

Reciprocally, an increased autophagic flux and the recycling of cellular macromolecules upon extended inhibition of mTORC1 is sufficient to partially replenish intracellular or intra-lysosomal amino acid pools and to partially reactivate mTORC1 (Yu et al., 2010