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Description

In the ferroptotic cell death model, lapatinib exerted neuroprotection via restoring glutathione peroxidase 4 (GPX4)

This is because antioxidants have more work to do and more oxidants to mop up before their effects start to be felt/seen

This supports its use in TM and highlights its potential for development as an anti-HTN drug (274)

doi: 10.1101/gad.275891.115 76 ZhangYZhuangLGanB

Incorporated as selenocysteine, it provides the catalytic power needed for efficient peroxide reduction, far surpassing what cysteine-based variants can achieve