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354 In addition, amitriptyline can increase the expression of Cx43 to promote gap junction intercellular communication (GJIC) between astrocytes, thereby relieving depressive symptoms

Although nicotinic acid was first isolated in 1867, its role as the active vitamin was not identified until 1937, when black tongue in dogs was used as an animal model of pellagra (5)

DOI: 10.1016/S0898-8838(00)51001-0 3

In patients with severe AH, approximately 25% will present with evidence of sepsis, and a further 30% may experience bacterial or fungal infection during the hospital admission

Targeted Action: Theoretically initiates the healing cascade precisely where it's needed most