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USP22 also deubiquitinates RIPK3, which causes high hyperglycemia to trigger damage to podocyte intercellular collagenization while targeting USP22 increased the amount of ubiquitinated degradation of RIPK3 and protected podocytes[97]

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Bevacizumab is a drug approved for the treatment of several forms of cancer, such as lung, kidney, ovarian and mammary gland cancer

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This multifaceted disruption impairs the BBBs normal homeostatic roles and directly influences neural activity