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Hoffman, J

The speed at which scientific progress is happening is not keeping pace with its health applications

More recent studies further extend its protective profile by demonstrating that salidroside limits regulated cell death pathways, including ferroptosis, pyroptosis, and PANoptosis, through coordinated regulation of PI3K/AKT, Nrf2-dependent antioxidant signaling, and hypoxia-responsive pathways, thereby preserving tubular and microvascular integrity in ischemic, septic, and crystal-associated AKI models (Tang et al

Externalized PS induces thrombin generation via factor X activation

To identify the target that mediates this effect, we applied thermal proteome profiling (TPP) and uncovered the disulfide reductases GSR and TXNRD1 as LCS3 targets